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nuebiome face serum for microbiome balance
nuebiome anti-aging face serum probiotic skincare
award winning nighttime face serum
nuebiome anti aging face serum for hydrated skin
Premium Skin Firming with Nuebiome's Peony Probiotic Night Serum
Top Rated Peony Extract Night Serum for Fine Lines and Brightening

Empris-Peony™ Biotic Resurfacing Night Serum


all skin types

All Skin Types

Night Time

fine lines and wrinkles

Fine Lines and Winkles

firming cream


dull skin


healthy skin

Healthy Aging

Size34 mL

Crafted with a powerful mix of probiotic bioferments and gentle flower acids, this face serum expertly resurfaces skin, peeling away dead cells for a smoother, firmer appearance by morning. Infused with peptides and antioxidants, it ensures lasting clarity and smoothness, revitalizing your skin's natural glow.

Why It Works

Skin rejuvenation: Peony root and kangaroo apple deliver antioxidant and potent bioferments revitalize skin for a lustrous and more youthful appearance.

Overnight cellular renewal: Cell-renewing prebiotics, probiotics, postbiotics and emollients help soothe irritation and maintain the skins natural moisture barrier for clear and soft skin.

Anti-aging: Peony root extracts helps reduce the appearance of wrinkles, inhibits blue light photodamage and energizes skin surface layers.

First of its kind: Formulated using dormant, living cells of Lactobacillus crispatus, a beneficial microorganism naturally occurring on young skin.

Probiotic Bioferments

Prebiotics: Inulin, Alpha-Glucan Oligosaccharide

Probiotics: Lactobacillus crispatus, Lactobacillus Ferment Lysate Filtrate

Postbiotics: Black Tea Ferment

cruelty free certified by leaping bunny no animal testing
cruelty free certified vegan products PETA approved
Carbon-neutral shipping with Shopify Planet
Carbon-neutral shipping on all orders

Featured In

Natural Peony Bioferment Serum for Youthful Skin - Shop Nuebiome

About the serum


For rejuvenated and glowing skin by morning, integrate the Empris-Peony™ Serum into your nightly regimen

Cleanse: Start with a gentle cleanser to remove impurities and prepare your skin.

Tone: Apply toner to balance your skin's pH and enhance serum absorption.

Empris-Peony™ Serum: Dispense a single pump of the face serum and apply evenly across your face, focusing on areas needing extra attention for texture and radiance.

Moisturize: Seal in the serum's benefits with your favorite moisturizer, promoting overnight hydration and repair.

This routine leverages the serum's bioferment and gentle flower acids to support skin's natural renewal process, leaving it smooth, firm, and radiant.

Quick Daytime Boost with Empris-Peony™ Serum an instant morning glow

Splash with Water: Begin by splashing your face with water to wake up your skin.

Empris-Peony™ Serum: Apply a half pump of the face serum for a quick absorption and immediate glow. Its lightweight formula won't weigh down your skin, making it perfect for daytime use.

Sunscreen: Finish with a broad-spectrum sunscreen to protect your skin from UV damage and maintain the serum's benefits.

This quick, two-step routine ensures your skin is protected, hydrated, and radiantly glowing, ready to face the day.


The Empris-Peony™ Biotic Resurfacing Night Serum combines probiotic bioferments, gentle flower acids and peptides delivering a luminous and smooth complexion with clean ingredients. This lightweight, fast-absorbing formula suits all skin types, promoting a radiant appearance.

Microbiome Friendly:

Clinically tested and certified, the Empris-Peony™ face serum is proven to maintain the skin microbiome balance, ensuring healthy skin. This focus on the microbiome promotes long-term skin health and equilibrium.

Suitability for Acne-prone, Oily Skin:

Perfect for acne-prone skin, the serum's probiotic bioferments aid in maintaining clear pores and balanced skin. Its mica-free, lightweight texture ensures a glowing complexion for all skin types, including oily skin.

Age and Skin Type:

Designed for anyone seeking to enhance their skin's radiance and texture, the face serum is appropriate for all ages and skin types. It's particularly effective at strengthening the skin barrier and evening out skin tone.

Application Around Eyes:

The nigh serum is not recommended for use around the eyes, to maintain the safety and health of the delicate eye area.


In alignment with Nuebiome's commitment to clean, scientifically-formulated products, our serum is free from synthetic fragrances. It's naturally scented with essential oils, including bitter almond, coriander, bergamot, and sandalwood, offering a safe and enjoyable experience for all skin types, even sensitive ones.


Peptides: A powerful amino acids that dramatically reduces the appearance of fine lines and wrinkles, enhancing skin’s firmness and elasticity.

Niacinamide (Vitamin B₃) Powerful vitamin and antioxidant that helps to erases blemishes and reduce the signs of aging, while helping to diminish the congestion caused by daily topical product use.

Glycolic & Flower Acids: AHAs, which refines skin texture, revives dull looking skin and penetrates deep to speed up skin surface turnover.

Peony Root: Detoxifies and rejuvenates the skin. Increased synthesis of collagen and decreases the breakdown of cells.

clean non-toxic probiotic skincare


Our strict standards exclude health offenders like parabens, phthalates, sulfates, PEGs, chemical sunscreens and EDTA to name a few.

See our 100+ skincare ingredients to avoid.

nuebiome  nontoxic skincare beauty ingredients


We've gone even further to exclude controversial ingredients like irradiated bacteria, drying alcohols, mineral oils, animal fats, all silicone derivatives like dimethicone, artificial colors and fragrances due to their negative effects on maintaining the skin's balance.


Clean. Effective. Biocompatible.

We're constantly working to formulate the highest quality clean skincare collection that's wholly bioferment and plant-derived.

Effective Means High Performing

Our clinician-developed formulas use only clinically proven high quality probiotic ingredients at active levels.

Clean Means Safe

Our formulas are made without ingredients shown or suspected to harm human health. 100+ toxic skincare ingredients to avoid.

pH Means Equilibrium

We formulate with special attention to the natural pH of the skin barrier and acid mantle. When pH is optimized the skin is better able to defend against pathogenic microorganisms and recognize compatible ingredients.

Made in the USA

We are designed, formulated and produced in the USA at an FDA certified facility.

Grounded in Research

Every ingredient is evaluated for functionality, safety and performance.

Discover Our
Triple Probiotic Blend

Plant based natural probiotic skincare ingredients

Research-Focused Ingredients

We source premium plant ingredients with natural anti-aging effects to rejuvenate your skin.

probiotic skincare serum for glowing hydrated skin

Biome-Targeted Fermentation

Unique fermentation and filtration process isolating potent bacterial elements to enhance skin conditioning.

probiotic skincare

Deep Cellular Hydration

Our nighttime serum's bioferment blend nourishes skin, locking in moisture for rejuvenation.